Robert A Harris Selected Research

pyruvate dehydrogenase kinase 4

1/2017	Pyruvate dehydrogenase kinase 4 deficiency attenuates cisplatin-induced acute kidney injury.
1/2016	Corrigendum: Pyruvate Dehydrogenase Kinase 4 Promotes Vascular Calcification via SMAD1/5/8 Phosphorylation.
11/2015	Pyruvate Dehydrogenase Kinase 4 Promotes Vascular Calcification via SMAD1/5/8 Phosphorylation.
5/2012	Additive effects of clofibric acid and pyruvate dehydrogenase kinase isoenzyme 4 (PDK4) deficiency on hepatic steatosis in mice fed a high saturated fat diet.
1/2012	Hypoxia induces PDK4 gene expression through induction of the orphan nuclear receptor ERRγ.
2/2008	Overexpression of pyruvate dehydrogenase kinase 4 in heart perturbs metabolism and exacerbates calcineurin-induced cardiomyopathy.
3/2006	Retinoic acids and trichostatin A (TSA), a histone deacetylase inhibitor, induce human pyruvate dehydrogenase kinase 4 (PDK4) gene expression.

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Robert A Harris Research Topics

Disease

22	Neoplasms (Cancer) 01/2022 - 02/2002
16	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 01/2022 - 07/2002
14	Multiple Sclerosis 01/2022 - 06/2003
12	Inflammation (Inflammations) 02/2021 - 03/2008
10	Hypoxia (Hypoxemia) 01/2021 - 01/2004
10	Insulin Resistance 01/2019 - 07/2008
8	Neuroinflammatory Diseases 01/2022 - 09/2010
8	Obesity 01/2021 - 07/2008
6	Demyelinating Diseases (Demyelinating Disease) 10/2021 - 07/2002
6	Starvation 01/2019 - 02/2002
5	Mitochondrial Diseases (Mitochondrial Disease) 01/2021 - 02/2012
4	Infections 01/2020 - 12/2002
4	Ischemia 10/2017 - 02/2008
4	Hyperglycemia 03/2016 - 05/2007
4	Type 2 Diabetes Mellitus (MODY) 03/2014 - 09/2009
3	Reperfusion Injury 10/2017 - 03/2010
3	Vascular Calcification 01/2016 - 02/2012
3	Fibrosis (Cirrhosis) 01/2016 - 02/2008
3	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 03/2009 - 07/2005
2	Neurodegenerative Diseases (Neurodegenerative Disease) 04/2022 - 01/2017
2	Autoimmune Diseases (Autoimmune Disease) 01/2022 - 11/2012
2	Metabolic Diseases (Metabolic Disease) 01/2021 - 03/2017
2	Alcoholism (Alcohol Abuse) 12/2019 - 01/2015
2	Sepsis (Septicemia) 01/2019 - 07/2010
2	Glioma (Gliomas) 11/2018 - 06/2008
2	Alcoholic Liver Diseases (Alcoholic Liver Disease) 03/2017 - 12/2015
2	Liver Diseases (Liver Disease) 03/2017 - 01/2006
2	Acute Kidney Injury (Acute Renal Failure) 01/2017 - 03/2004
2	Hypersensitivity (Allergy) 03/2016 - 10/2015
2	Pain (Aches) 03/2016 - 10/2015
2	Melanoma (Melanoma, Malignant) 01/2016 - 12/2014
2	Hepatocellular Carcinoma (Hepatoma) 03/2015 - 01/2012
2	Cardiomegaly (Heart Hypertrophy) 04/2013 - 02/2008
2	Prostatic Neoplasms (Prostate Cancer) 01/2013 - 01/2012
2	Body Weight (Weight, Body) 05/2012 - 09/2009
2	Dyslipidemias (Dyslipidemia) 05/2012 - 05/2007
2	Breast Neoplasms (Breast Cancer) 06/2005 - 02/2002
1	Leukoencephalopathies 12/2020

Drug/Important Bio-Agent (IBA)

17	Glucose (Dextrose)FDA LinkGeneric 01/2019 - 02/2002
13	Proteins (Proteins, Gene)FDA Link 01/2022 - 02/2002
9	Pyruvate Dehydrogenase Acetyl-Transferring KinaseIBA 01/2021 - 08/2006
9	Myelin-Oligodendrocyte GlycoproteinIBA 09/2020 - 07/2002
8	Pyruvic Acid (Pyruvate)IBA 01/2021 - 04/2004
8	Insulin (Novolin)FDA Link 01/2019 - 02/2002
8	Pyruvate Dehydrogenase Complex (Dehydrogenase Complex, Pyruvate)IBA 10/2016 - 06/2003
7	Oxidoreductases (Dehydrogenase)IBA 01/2021 - 04/2004
7	Phosphotransferases (Kinase)IBA 01/2021 - 02/2002
7	pyruvate dehydrogenase kinase 4IBA 01/2017 - 03/2006
7	Messenger RNA (mRNA)IBA 01/2012 - 02/2002
5	Lactic Acid (Lactate)FDA LinkGeneric 01/2021 - 08/2008
5	IsoenzymesIBA 10/2019 - 06/2003
5	Oxygen (Dioxygen)IBA 03/2016 - 02/2008
5	Fatty Acids (Saturated Fatty Acids)IBA 05/2012 - 02/2002
4	DNA (Deoxyribonucleic Acid)IBA 01/2022 - 04/2004
4	CytokinesIBA 05/2020 - 05/2014
4	EnzymesIBA 03/2016 - 03/2004
3	Pharmaceutical PreparationsIBA 02/2021 - 01/2015
3	Biomarkers (Surrogate Marker)IBA 01/2020 - 04/2010
3	Peptides (Polypeptides)IBA 01/2017 - 04/2004
3	Reactive Oxygen Species (Oxygen Radicals)IBA 11/2016 - 02/2012
3	Transcription Factors (Transcription Factor)IBA 01/2012 - 01/2004
3	Protein Isoforms (Isoforms)IBA 01/2012 - 02/2002
3	Blood Glucose (Blood Sugar)IBA 07/2008 - 03/2006
2	Therapeutic UsesIBA 01/2022 - 05/2014
2	Phosphoric Monoester Hydrolases (Phosphatases)IBA 01/2021 - 02/2008
2	AntibodiesIBA 10/2019 - 01/2016
2	Interleukin-17 (Interleukin 17)IBA 01/2018 - 03/2008
2	Nitric Oxide (Nitrogen Monoxide)FDA Link 10/2017 - 01/2016
2	Cisplatin (Platino)FDA LinkGeneric 01/2017 - 03/2004
2	Interleukin-12 (IL 12)IBA 11/2016 - 05/2012
2	Streptozocin (Streptozotocin)FDA Link 03/2016 - 06/2003
2	Adenosine (Adenocard)FDA LinkGeneric 01/2016 - 07/2015
2	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 01/2016 - 05/2012
2	Phosphates (Orthophosphate)IBA 11/2015 - 02/2012
2	Tretinoin (Retinoic Acid)FDA LinkGeneric 03/2015 - 02/2010
2	LigandsIBA 01/2013 - 03/2004
2	Choline (Choline Chloride)IBA 01/2012 - 06/2008
2	Prolyl Hydroxylases (Prolyl Hydroxylase)IBA 03/2010 - 02/2008
2	Small Interfering RNA (siRNA)IBA 03/2010 - 08/2008
2	AutoantigensIBA 05/2008 - 07/2007
1	Colony-Stimulating Factors (Colony Stimulating Factor)IBA 04/2022
1	CamptothecinIBA 01/2022
1	karonudibIBA 01/2022
1	Topotecan (Hycamtin)FDA LinkGeneric 01/2022
1	9 alpha,11 alpha,15 alpha- trihydroxy- 16- phenoxy- 17,18,19,20- tetranorprosta- 4,5,13- trienoic acid (TPT)IBA 01/2022
1	NucleotidesIBA 01/2022
1	2- cyclohexylidenhydrazo- 4- phenyl- thiazoleIBA 01/2022
1	RNA (Ribonucleic Acid)IBA 10/2021
1	Hyaluronic Acid (Hyaluronan)IBA 02/2021
1	Doxorubicin (Adriamycin)FDA LinkGeneric 02/2021
1	Dexamethasone (Maxidex)FDA LinkGeneric 02/2021
1	MicellesIBA 02/2021
1	Macrophage Colony-Stimulating FactorIBA 12/2020
1	Neuroprotective AgentsIBA 11/2020
1	Tamoxifen FDA LinkGeneric 09/2020

Therapy/Procedure

10	Therapeutics 02/2021 - 06/2003
5	Immunotherapy 11/2019 - 11/2012
2	Immunomodulation 05/2020 - 07/2005
2	Ligation 05/2012 - 02/2012
1	Hematopoietic Stem Cell Transplantation 12/2020